Interesting how many of these compounds have CNS/BBB relevance ā it makes the combination feel very GBM-specific. I suspect these are also an important backbone in other cancers where brain mets are a risk (such as HER2 breast cancer).
Iām also curious about the valganciclovir angle: do you see a role for CMV targeting beyond GBM, especially in patients with high IgG, or is that context-dependent?
I recently wrote a deeper dive on Turkey Tail and its immune effects if helpful:
BBB penetrance is half the reason the stack holds up, and I think it does translate. HER2+ breast with brain met risk is where I lean on a similar backbone, especially mebendazole, metformin, and nighttime melatonin.
On valganciclovir, I treat it as context-dependent. High CMV IgG alone is not enough. I want active signal, rising titers, PCR positivity, or a clinical picture that fits reactivation. Interesting data exists in medulloblastoma, neuroblastoma, and some breast and colon work, but outside GBM it is thinner.
Will read the Turkey Tail piece! Thank you for sharing.
And since weāre on it, melatonin is definitely important. But tolerability (from a sleepiness level the next day) is pretty hard if going into onco dosing. What is your thought on this.
Interesting how many of these compounds have CNS/BBB relevance ā it makes the combination feel very GBM-specific. I suspect these are also an important backbone in other cancers where brain mets are a risk (such as HER2 breast cancer).
Iām also curious about the valganciclovir angle: do you see a role for CMV targeting beyond GBM, especially in patients with high IgG, or is that context-dependent?
I recently wrote a deeper dive on Turkey Tail and its immune effects if helpful:
https://thecancerstrategist.substack.com/p/how-a-strange-mushroom-became-one
BBB penetrance is half the reason the stack holds up, and I think it does translate. HER2+ breast with brain met risk is where I lean on a similar backbone, especially mebendazole, metformin, and nighttime melatonin.
On valganciclovir, I treat it as context-dependent. High CMV IgG alone is not enough. I want active signal, rising titers, PCR positivity, or a clinical picture that fits reactivation. Interesting data exists in medulloblastoma, neuroblastoma, and some breast and colon work, but outside GBM it is thinner.
Will read the Turkey Tail piece! Thank you for sharing.
And thanks for the thorough reply on my other question:)
And since weāre on it, melatonin is definitely important. But tolerability (from a sleepiness level the next day) is pretty hard if going into onco dosing. What is your thought on this.